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Allergan, Ironwood Seek To Divide And Conquer IBS With New Linzess Formulations

 
• By Alexandra Shimmings

Allergan and Ironwood Pharmaceuticals are beefing up the blockbuster potential of their IBS drug Linzess with two new formulations that target different disease populations showing promising Phase II data. Further Phase IIb and III trials are now in the offing.

IBS
• Source: Shutterstock

Allergan PLC and Ironwood Pharmaceuticals Inc. have released promising topline Phase IIb data for two novel formulations of their irritable bowel syndrome (IBS) treatment Linzess (linaclotide) that they hope will boost the franchise for many years to come by offering better and faster pain relief in constipation-predominant patients and opening up the product for use in other IBS subtypes, and possibly even other GI disorders.

The two formulations, known as CR1 and CR2, are designed to deliver the drug at two separate locations in the gastrointestinal tract where they are expected to produce slightly

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