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Colorectal Cancer: Isofol’s Modufolin Could Change Mainstay Therapy

 
• By John Davis

Decades-long academic and pharma research to improve on the benefits of the 5-fluorouracil and Leucovorin combination in colorectal cancer has reached a crucial point, with a multinational Phase III pivotal trial of Isofol’s Modufolin being cleared by regulators but funding is still needed.

Gothenberg, Sweden-based biotech Isofol Medical AB expects to start a pivotal Phase III study at the end of 2017 with its single asset, Modufolin, potentially a more effective product to combine with 5-fluorouracil (5-FU) than conventional Leucovorin (folinic acid).

The company is currently working on raising new funds for the study that could include an initial public offering. Over...

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