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PhaseRx Makes More Noise Than Silence With mRNA Delivery

 
• By Mike Ward

Having ditched silence RNA in 2012, PhaseRx president and CEO Dr Robert Overell explains to Mike Ward, global director of content at Informa Pharma Intelligence’s insights portfolio, how delivering messenger RNA inside diseased cells may revolutionize and grow the current $4bn enzyme replacement market.

RNA-based medicines have had a checkered development history, including a mixed bag of results last year at some of the leading players such as Alnylam Pharmaceuticals Inc. and Moderna Therapeutics LLC. Following its false start with siRNA, Seattle-based PhaseRx Inc., which raised $18.5m in a May 2016 IPO (and has raised about $70m since its formation in 2006), is focusing on mRNA and has developed a technology that combines a lipid nanoparticle (LNP) carrier with a proprietary polymer.

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