Bristol Shrugs Off Lirilumab Phase II Mono Trial Failure; Eyes Combo Trials

Bristol says its combination development program for lirilumab - licensed from Innate Pharma in 2011 – remains unaffected by news the anti-KIR checkpoint inhibitor failed in a Phase II trial in elderly patients with acute myeloid leukemia as a maintenance monotherapy.

Clinical trial

Innate Pharma SA and partner Bristol-Myers Squibb Co. moved quickly to reassure investors that their cancer drug lirilumab remains on track for combo trialing in both solid and liquid tumors despite the drug's failure in the Phase II EffiKIR trial to hit its main endpoint of leukemia-free survival (LFS).

EffiKIR, sponsored by Innate to assess the efficacy of lirilumab as a single-agent maintenance for senior patients with AML in its first complete remission, found no statistically significant difference in LFS or other efficacy endpoints between the trial’s placebo arm and its two treatment arms

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