Johnson & Johnson reported positive results for its IL-23 inhibitor guselkumab against AbbVie Inc.’s anti-tumor necrosis factor drug Humira in the VOYAGE-2 psoriasis study, the second positive Phase III head-to-head study in the indication, following VOYAGE-1.
The drug met a co-primary endpoint related to improvement after 16 weeks in disease severity, measured by the Psoriasis Area Severity Index-90 (PASI 90), meaning a 90% improvement or almost complete skin clearance: 70% for test drug versus 2.4% for placebo
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