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Pfizer Takes Step Back With Avelumab, Step Forward On CAR-T

 
• By Emily Hayes

Major changes to Phase III Lung 100 study of PD-L1 inhibitor avelumab mean a big delay for development in first-line lung cancer, but, separately, Pfizer advances in allogeneic CAR-T therapy with partners Servier and Cellectis.

T-cell

Pfizer Inc. has taken a step backward with the development of its PD-L1 inhibitor avelumab in lung cancer, the most valuable indication for checkpoint inhibitors, but the firm's efforts to build in immuno-oncology are advancing in another important area through an IND for an off-the-shelf CAR-T candidate, in partnership with Servier SA and Cellectis SA.

Avelumab, which is partnered with Merck KGAA'sEMD Serono Inc., has trailed behind development of the leaders in the family of PD-1/L1 checkpoint inhibitors – Bristol-Myers Squibb Co.'s...

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Pipeline Watch: 12 Approvals And 26 Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.