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ALEX Ups The Ante For Alecensa In ALK+ NSCLC

 
• By Alexandra Shimmings

Roche's Alecensa has bested Pfizer's Xalkori in the Phase III head-to-head ALEX study in first-line non-small-cell lung cancer, making a strong case for it to be the new gold standard therapy in ALK-positive patients, in favor of Novartis's Zykadia.

Adenocarcinoma
Adenocarcinoma Cells • Source: Shutterstock

Roche 's second-generation ALK inhibitor Alecensa (alectinib) has shown a significant improvement over Pfizer Inc. 's first-generation product Xalkori (crizotinib) in progression-free survival when used first-line in advanced ALK-positive non-small cell lung cancer (NSCLC).

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