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Argos Not Stopping Cancer Vaccine Study Despite Futility

 
• By Joseph Haas

The biotech suggests that ADAPT trial design was not ideally structured to show the longer-term benefit that might result from its autologous immunotherapy. Argos plans to discuss its plan with FDA in May, despite analyst skepticism.

Cancer cells

Argos Therapeutics Inc. wants to finish out the Phase III ADAPT trial of its personalized immunotherapy for metastatic renal cell carcinoma (mRCC) despite an interim data review that indicates lower median overall survival compared to control and a recommendation by the independent data monitoring committee that the study be terminated.

In an April 18 investor call to review the data and its rationale for continuing the trial, North Carolina-based Argos asserted that while an overall survival benefit was not seen...

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