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Veliparib Phase III Failures Strike Blow To AbbVie's Oncology Strategy

 
• By Sten Stovall and Emily Hayes

The failure of veliparib in Phase III studies of squamous NSCLC and triple-negative breast cancer is a blow for AbbVie's oncology pipeline, but may not have implications for other PARP inhibitors in new tumor types.

Archery

AbbVie Inc.'s oncology strategy has taken a hit with news of the failure of its investigational PARP inhibitor veliparib in two Phase III studies that tested the drug in combination with chemotherapy in first-line squamous non-small cell lung cancer (NSCLC) and in early stage triple-negative breast cancer.

In one of the trials, the combination treatment failed to improve the overall survival of previously untreated metastatic, squamous NSCLC patients who had smoked within the past 12 months and had more

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Pipeline Watch: Thirteen Approvals And Ten Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.