Veliparib Phase III Failures Strike Blow To AbbVie's Oncology Strategy

The failure of veliparib in Phase III studies of squamous NSCLC and triple-negative breast cancer is a blow for AbbVie's oncology pipeline, but may not have implications for other PARP inhibitors in new tumor types.

Archery

AbbVie Inc.'s oncology strategy has taken a hit with news of the failure of its investigational PARP inhibitor veliparib in two Phase III studies that tested the drug in combination with chemotherapy in first-line squamous non-small cell lung cancer (NSCLC) and in early stage triple-negative breast cancer.

In one of the trials, the combination treatment failed to improve the overall survival of previously untreated metastatic, squamous NSCLC...

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