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Alnylam Plays Up Patisiran As Polyneuropathy Drug Nears Filings

 
• By Joseph Haas

Open-label extension Phase II data with RNAi candidate shows patients with transthyretin-mediated amyloidosis polyneuropathy may be regaining sensation and possibly even regenerating nerves.

Neurons and nervous system. 3d render of nerve cells

Pivotal Phase III data are expected in September for patisiran, Alnylam Pharmaceuticals Inc.'s most advanced RNA-interference candidate, but the biotech is also releasing long-term data from its successful Phase II study indicating the polyneuropathy drug improves sensation and possibly even regenerates nerves.

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