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Shire Discontinues Development Of Once-Weekly SHP656 For Hemophilia A

 
• By Mandy Jackson

Shire's cash-strapped partner Xenetic, whose technology enabled the long-acting Factor VIII, said on May 22 that SHP656 could not achieve once-weekly dosing in a Phase I/II clinical trial. The market for such a product may be limited anyway given current competition and payer preferences.

3-D Rendering Red Blood Cells

Xenetic Biosciences Inc. revealed on May 22 that its partner Shire PLC ended development of SHP656 for hemophilia A, because the long-acting coagulation Factor VIII could not be dosed once-weekly, which eliminates the product candidate's best chance for differentiation in the marketplace.

Physicians, patients and especially payers are looking for hemophilia therapies that can be dosed once-weekly or less frequently to reduce the burden and cost of infusions required two to four times per week under the dosing regimens of approved Factor VIII products (see sidebar). With dosing required more often than once per week, SHP656 wouldn't be much different from Bioverativ Inc

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