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Disappointing Bydureon EXSCEL Outcomes Data May Raise Stakes For Victoza

 
• By Emily Hayes

AstraZeneca's EXSCEL study could have created confidence in a GLP-1 class-wide outcomes benefit, but instead it has raised questions about whether differences in trial results boil down to trial design.

The failure of AstraZeneca PLC's GLP-1 receptor agonist Bydureon to prove superior efficacy over placebo in the largest outcomes study of a diabetes drug completed to date may make physicians question the robustness of the cardiovascular benefit for Novo Nordisk AS's Victoza, some analysts say.

The Phase IIIb/IV EXSCEL study tested the once-weekly injectable Bydureon (exenatide extended release) against placebo, both on top of standard of-care therapy in more than 14,000 patients

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