Advaxis Zips Listeria/Opdivo Combo Straight To Registrational Cervical Cancer Trial

Potentially registrational trial of ADXS-DUAL Listeria-based vaccine with Bristol's PD-1 inhibitor Opdivo in recurrent metastatic cervical cancer will complement Advaxis's adjuvant study of earlier-generation candidate axalimogene filolisbac.

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Advaxis Inc. plans to start a randomized study by the end of the year for its Listeria-based vaccine ADXS-DUAL with Bristol-Myers Squibb Co.'s PD-1 inhibitor Opdivo (nivolumab) in recurrent metastatic cervical cancer, in hopes that it could serve as a registrational trial, given the small patient population and high unmet need.

Advaxis and Bristol announced their plans to collaborate on a study of squamous and non-squamous cell cervical cancer on May 30

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