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Loxo's Larotrectinib Requires Paradigm-Change In Clinical Practice

 
• By Mary Jo Laffler

The TRK inhibitor won over ASCO with deep and durable responses across 17 cancer types, but diagnostics will be the true test of the tumor-agnostic approach – and the focus of Loxo's commercial strategy.

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Having demonstrated a 76% response rate with deep and durable responses, Loxo Oncology Inc. revealed impressive pivotal data for larotrectinib, which seems poised for approval next year; the challenge now lies in awareness and adoption of testing that's required to identify the TRK fusion abnormality the drug targets.

"Testing is the key question," Loxo Chief Business Officer Jacob Van Naarden told Scrip June 3 in an interview at the American Society of Clinical Oncology meeting in Chicago, where the data were presented by

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