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APHINITY Combo Details Contain No Surprise, Puma's Nerlynx May Benefit

 
• By Sten Stovall and Lucie Ellis-Taitt

Details of Roche's early stage breast cancer study APHINITYs were positive as previously headlined, but it's likely to confine use of Perjeta, Herceptin and chemotherapy to higher-risk, node-positive patients.

Mature female doctor assisting young patient undergoing mammogram

Details of Roche's positive Phase III APHINITY trial examining use of Perjeta (pertuzumab), Herceptin (trastuzumab) and chemotherapy together in the adjuvant treatment of breast cancer underwhelmed analysts at this year's ASCO meeting in Chicago and prompted many to say the combo's use is likely to be limited to node-positive patients.

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