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Actelion Setback Ahead Of J&J Deal Closure

 
• By Sukaina Virji

A setback for Actelion – and Johnson & Johnson – as it reports mixed Phase III data for the Clostridium difficile treatment candidate cadazolid.

3D illustration of Clostridium difficile bacteria. Bacteria which cause pseudomembraneous colitis and are associated with nosocomial antibiotic resistance
Clostridium difficile bacteria in 3D

Actelion Pharmaceuticals Ltd. has reported one hit and one miss in the Phase III IMPACT program of its novel anti-infective cadazolid versus vancomycin in the treatment of Clostridium difficile-associated diarrhea (CDAD). The program is one that will be taken over by Johnson & Johnson shortly when the healthcare giant completes its $30bn acquisition of Actelion, expected in the coming weeks.

In the pivotal program for cadazolid, IMPACT 1 met its primary endpoint, while the identical second study IMPACT 2 did...

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