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ASCO Upsets CDK4/6 Class: Strong Data For Lilly's Abemaciclib, But Pfizer's Ibrance Disappoints

 
• By Emily Hayes

CDK4/6 inhibitors offer impressive progression-free survival data in breast cancer, but lack of overall survival data may mean the class will be relegated to the second-line setting.

Dividing breast cancer cell

Phase III progression-free survival data from the MONARCH 2 study presented at the American Society of Clinical Oncology meeting put Eli Lilly & Co. in a good position to file the CDK4/6 inhibitor abemaciclib in the second quarter as planned, though a different release by rival Pfizer Inc.'s Ibrance raised questions about whether the class will be able to show an overall survival benefit.

MONARCH 2 tested abemaciclib with the selective estrogen receptor degrader fulvestrant in 669 hormone-receptor positive (HR+), human epidermal growth factor...

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Pipeline Watch: Eight Approvals And Ten Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.