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Pfizer's Xeljanz Is First JAK Positive In PsA But Challenges Ahead

 
• By Ines Mihel and Christina Vasiliou

Pfizer’s oral JAK inhibitor Xeljanz is set to lead the JAK inhibitors to market in psoriatic arthritis following positive Phase III data particularly in joint inflammation, but skin findings were disappointing.

Rheumatologists suggested Pfizer Inc.'s Xeljanz (tofacitinib) will be a suitable treatment option for patients with heavy joint involvement and minimal skin disease, or patients not concerned about their skin symptoms, after Pfizer unveiled pivotal Phase III data from the OPAL BEYOND and OPAL BROADEN studies in psoriatic arthritis (PsA) at the recent European League Against Rheumatism (EULAR) meeting in Madrid, Spain.

Xeljanz is expected to be the first-in-class JAK inhibitor in PsA. In May, the FDA accepted for review a supplemental New Drug Application (sNDA) for Xeljanz 5mg twice daily, and...

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