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Big REVEAL: Merck's Anacetrapib Surprises With Success, But What Next?

 
• By Alexandra Shimmings

Merck & Co has triumphed against the odds announcing positive top-line results from the cardiovascular outcomes trial of its CETP inhibitor anacetrapib. But questions remain about the level of benefit and the regulatory prospects.

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Fallen Off Your Chair? A CETP Inhibitor Succeeds • Source: Shutterstock

Years after Pfizer Inc. dramatically discontinued the first CETP inhibitor torcetrapib – blowing a hole into a mechanism once hailed as the natural successor to the statins – Merck & Co. Inc. has breathed new life into the hypothesis by proving a cardiovascular outcomes advantage for its anacetrapib in the 30,000-patient REVEAL trial.

Merck announced June 27 that the CVOT study had met its primary endpoint, significantly reducing major coronary events (a composite...

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