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Alkermes ENLIGHTEN Hints At Efficacy Benefit But Weight Profile Still In Balance

 
• By Alexandra Shimmings

The first Phase III trial results for Alkermes' combination product for schizophrenia ALKS 3831 show hints of added benefit over olanzapine alone but no benefit yet on weight gain, the product's raison d'être. Analysts are hoping upcoming longer-term data will produce the goods.

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ENLIGHTEN Benefits Weighed In The Balance • Source: Shutterstock

The first of two Phase III ENLIGHTEN studies for Alkermes PLC's combination product for schizophrenia, ALKS 3831, show it has at least equivalent efficacy to olanzapine alone, but the study was too short to tell whether the combination can lessen the weight gain problem that plagues the older product.

The broad-spectrum antipsychotic product contains the novel drug samidorphan co-formulated with the established antipsychotic agent, olanzapine, in a single bilayer...

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