Alkermes ENLIGHTEN Hints At Efficacy Benefit But Weight Profile Still In Balance

The first Phase III trial results for Alkermes' combination product for schizophrenia ALKS 3831 show hints of added benefit over olanzapine alone but no benefit yet on weight gain, the product's raison d'être. Analysts are hoping upcoming longer-term data will produce the goods.

Zen stones
ENLIGHTEN Benefits Weighed In The Balance • Source: Shutterstock

The first of two Phase III ENLIGHTEN studies for Alkermes PLC's combination product for schizophrenia, ALKS 3831, show it has at least equivalent efficacy to olanzapine alone, but the study was too short to tell whether the combination can lessen the weight gain problem that plagues the older product.

The broad-spectrum antipsychotic product contains the novel drug samidorphan co-formulated with the established antipsychotic agent, olanzapine, in a single bilayer...

More from Clinical Trials

J&J’s Trispecific Antibody For Myeloma Offers Improved Safety, Potency Over Bispecifics

 

The drugmaker presented data from its Phase I study of JNJ-79635322 at ASCO and EHA showing a 100% response rate in BCMA- and GPRC5D-naïve patients.

ASCO: Pushing The Frontiers Of ADCs

 

Antibody-drug conjugates are a major part of the oncology pipeline, and data presented at the American Society of Clinical Oncology meeting highlight the emergence of new technologies.

Skyhawk Looks To Soar With Huntington’s Hope

 
• By 

Oral RNA splicing modulator has gone into a Phase II/III trial

Scholar Rock Shows Muscle-Building PoC In Obesity

 

The company said it intends to maintain a focus on rare neuromuscular disease with apitegromab but could consider partnering in obesity.

More from R&D

Spyre Takes Aim At Roche And J&J In Inflammatory Diseases

 

The US firm was already looking to compete in ulcerative colitis, but now expands its ambitions by moving into rheumatoid arthritis as well.

Ireland’s Got Biopharma Talent To Keep Leading The Pack

 
• By 

The country’s life sciences investment head tells Scrip that it is business as usual for the sector despite the rumblings from across the Atlantic.

Draig Is All Fired Up To Transform Neuropsychiatric Field

 
• By 

Wales-based group launches with $140m series A.