Neuralstem Plans Deep Dive Into Failed Phase II Major Depression Trial

Failure of NSI-189 in major depression study sends stock price down about 50% and next steps for development are unclear.

Neuralstem Inc. will be looking for new leads from a robust analysis of a failed Phase II study of its small molecule therapy NSI-189 in major depressive disorder (MDD) to guide next steps for the candidate.

According to the company, NSI-189 increases neurogenesis and stimulates volume in stem cells in the hippocampus, though its exact mechanism...

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