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PellePharm's Topical Patidegib Nears Phase III For Gorlin Syndrome

 
• By John Davis

Gel formulations of the hedgehog signalling inhibitor patidegib may be the long sought well-tolerated and effective therapy for basal cell carcinoma and the rare disease, Gorlin syndrome.

Carcinoma
A basal cell carcinoma • Source: Shutterstock

The US biotech PellePharm has announced positive top-line results from a UK-based Phase II trial of its novel topical hedgehog signaling pathway inhibitor, patidegib, in Gorlin syndrome and basal cell carcinoma. The company says it is aiming to start a Phase III study of the compound in the first half of 2018, following discussions with the US FDA, and supported by a planned Series C round of funding.

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