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Another Opdivo Disappointment For BMS, This Time In Kidney Cancer

 
• By Mandy Jackson

Bristol-Myers Squibb's Opdivo plus Yervoy in first-line RCC did not achieve statistical significance in terms of progression-free survival versus Sutent, but overall survival data aren't available yet.

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Bristol-Myers Squibb Co. reported once again that the combination of its blockbuster PD-1 inhibitor Opdivo (nivolumab) and CTLA-4 inhibitor Yervoy (ipilimumab) did not achieve statistical significance in a Phase III clinical trial – at least in terms of progression-free survival – but the ongoing first-line renal cell carcinoma (RCC) trial still could yield significant results in overall survival.

This is the second Phase III disappointment this year for Opdivo plus Yervoy after Bristol revealed in April that the...

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Henlius CEO Details PD-L1 ADC’s Path To 1L Mono/Combo Therapy

 
• By Dexter Jie Yan

Henlius is investigating the optimum dose for its PD-L1-targeting antibody-drug conjugate HLX43 to support potential first-line use, its CEO explains to Scrip.

UCB Follows Fellow European Pharmas With Major US Investment

 
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In Brief: Starton Moves Low-Dose Lenalidomide To Phase IIa For Multiple Myeloma

 
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Study to add to safety and tolerability data for infused formulation and may help identify optimal dose for future pivotal trial.

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Sanofi Revels In More Positive Rilzabrutinib Data

 
• By Kevin Grogan

The oral BTK inhibitor impresses in a Phase II trial for IgG4-related disease.

Is Zydus’s Agenus Deal Opportunistic Or Strategic?

 
• By Vibha Ravi

Will Zydus’s acquisition and licensing deal with Agenus turn out to be a strategic move towards building an oncology portfolio or an opportunistic one driven by a venture capital mindset?

How AstraZeneca Aims To Stay Ahead In Lupus As New Competition Looms

 
• By Andrew McConaghie

The company has established the efficacy of its biologic Saphenlo in systemic lupus erythematosus but is now investing across modalities to stay ahead of rivals.