Top-line data from the second of six Phase III studies of AbbVie Inc.'s investigational oral JAK1-selective inhibitor, upadacitinib (ABT-494), SELECT-BEYOND, show that it hit its endpoints in patients with moderate to severe rheumatoid arthritis who had not responded to, or were intolerant of, biological disease-modifying antirheumatic drugs (bDMARDs).
AbbVie's New Generation JAK inhibitor Looks Good But CV Specter Looms
More Phase III data for AbbVie's selective JAK1 inhibitor upadacitinib appear to back a potential best-in-class claim but eyes remain on safety after a death from pulmonary embolism.
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