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MURANO To Drive AbbVie/Roche's Venetoclax In CLL

 
• By Alexandra Shimmings

Top-line MURANO data support Venclexta's current conditional approvals and expand its use into a broader population that should radically boost sales.

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MURANO Data Buttressing Future Growth • Source: Shutterstock

AbbVie Inc. and Roche are in line for a sales boost for their BCL-2 inhibitor, Venclexta/Venclyxto (venetoclax), after top-line data show success for the Phase III MURANO study of the small-molecule drug in combination with the anti-CD20 product rituximab (Roche's MabThera/Rituxan) in relapsed or refractory chronic lymphocytic leukaemia (CLL), a far larger population than its current label covers.

The 389-patient trial has met its primary endpoint, giving a significant improvement in progression-free survival when used in combination with rituximab compared with bendamustine plus rituximab in this patient population

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• By Kevin Grogan

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• By Andrew McConaghie

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