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Ignyta's Entrectinib Data Sets Prospects Alight

 
• By Alexandra Shimmings

Interim data from STARTRK-2 study point to best-in-class status for Ignyta's entrectinib in a subset of non-small cell lung cancer patients – posing a threat to Xalkori. US NDA filings are set for 2018.

Star exploding
STARTRK data ignite etrectinib's prospects • Source: Shutterstock

San Diego, CA-based biotech Ignyta Inc. has revealed interim Phase II results for its lead product, the targeted anticancer entrectinib, that it believes show the drug to have best-in-class potential in non-small cell lung cancer (NSCLC).

Entrectinib is a potent and selective small molecule tyrosine kinase inhibitor of the TRK (tropomyosin receptor kinase) family of tyrosine kinase receptors (TRKA, TRKB and TRKC) and ROS1 proteins. ROS1...

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