Bristol's Opdivo Delivers, But CheckMate 227 Uncertainties Cloud Quarter

The use of the emerging tumor mutation burden biomarker and its relevance to the outcome of the CheckMate 227 study of Opdivo/Yervoy in first-line lung cancer was a hot topic during Bristol's Q3 earnings call, but questions remain.

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Bristol-Myers Squibb Co.'s PD-1 inhibitor Opdivo continues to deliver impressive sales despite increased competition, but uncertainties about the all-important CheckMate 227 study of combination use with Yervoy in first-line non-small cell lung cancer, including the relevance of tumor mutation burden as an emerging immuno-oncology biomarker, cast a bit of a cloud on the third quarter.

Bristol reported sales of about $1.3bn for Opdivo (nivolumab) for the third quarter, up 38% from the same period in 2016

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