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Auris Sees A Window To Treat Profound Hearing Loss Despite Phase III Failure

 
• By Jessica Merrill

The HEALOS trial testing AM-111 in sudden deafness did not meet the primary efficacy endpoint, but a subpopulation of patients with the worst hearing loss did show a statistically significant benefit.

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The first Phase III trial to test a drug treatment for acute hearing loss has failed. Auris Medical Holding AG announced the disappointing news for its Phase III HEALOS trial testing AM-111 Nov. 28, but provided a silver lining – a subpopulation of patients the company may continue to explore.

"Although the trial did not meet our expectations for the primary efficacy endpoint in the overall study population, we are...

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Pipeline Watch: Five Approvals And Two Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.