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BioLineRx's CXCR4 Antagonist: Promising For Stem Cell Mobilization And AML

 
• By John Davis

Numerous companies are evaluating CXCR4 antagonists in early-stage clinical studies for their potential in stem cell transplantation, acute myeloid leukemia and other disorders, and BioLineRx's lead compound appears to be a frontrunner in the race to market.

AML
• Source: Shutterstock

Tel Aviv, Israel-based biotech BioLineRx Ltd.'s lead product candidate, a short peptide, BL-8040, that acts as a CXCR4 chemokine receptor antagonist, has improved long-term overall survival in a Phase IIa study in patients with relapsed or refractory acute myeloid leukemia (AML), paving the way for more extensive studies of the compound in this difficult-to-treat group of patients.

BL-8040, a lead contender in the race to develop a better CXCR4 antagonist, when combined with high dose Ara-C (cytarabine) in the Phase IIa study, improved long-term overall survival compared with

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