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Promising Esketamine Remains On Track As Potential Depression Blockbuster

 
• By Sten Stovall

Published safety and efficacy Phase II data on J&J's esketamine highlights the antidepressant's potential, fanning interest in 2018 pivotal read-outs.

Neurons and nervous system. 3d render of nerve cells
• Source: Shutterstock

Excitement over Johnson & Johnson's esketamine has been fanned by publication of promising Phase II safety and efficacy data in which the anti-depressant showed significant, clinically meaningful and rapid improvement of depressive symptoms as compared with intranasal placebo, in patients with treatment-resistant depression.

The data, published Dec 29, 2017 in JAMA Psychiatry detailing the company's Phase II SYNAPSE trial, will heighten anticipation for...

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