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Pfizer May Enjoy Blockbuster Cardiomyopathy Success With Tafamidis

 
• By Joseph Haas

Although tafamidis has been stalled at FDA for transthyretin-mediated polyneuropathy, Pfizer may have found a different path toward US approval with cardiovascular outcomes data in cardiomyopathy.

Anatomy of Human Heart

Pfizer Inc. may have an unexpected blockbuster opportunity on its hands, as it reported significant cardiovascular outcomes data March 29 from a Phase III study of tafamidis meglumine in transthyretin-mediated cardiomyopathy. Approved overseas as Vyndaqel, tafamidis has been tied up since 2012 at US FDA for the related indication of familial amyloid polyneuropathy (FAP).

Informa Pharma Intelligence's Biomedtracker called the top-line data from Pfizer's Phase III ATTR-ACT study "quite encouraging," while an Evercore ISI...

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