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New Data Cast Doubt On Gilead's Phase III NASH Candidate Selonsertib

 
• By Joseph Haas

Gilead presented early data for combinations of its three mechanisms in NASH, but analysts noted the findings may undercut its lead candidate selonsertib. Plus EASL takeaways for Genfit, NGM and Madrigal.

scientists doing lab research on digital screen

Coming out of the 2018 International Liver Congress, some analysts think the latest data presented by Gilead Sciences Inc. pose questions about the efficacy of its lead candidate for non-alcoholic steatohepatitis (NASH), selonsertib. But other companies in the close race to bring the first NASH therapy to market, such as NGM Biopharmaceuticals Inc. and Madrigal Pharmaceuticals Inc., received more positive reception for their updates.

Selonsertib, an apoptosis-signaling kinase 1 (ASK1) inhibitor, received mixed reviews following the presentation of a proof-of-concept trial testing different combinations...

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