Next-Generation CAR-Ts Tackle First-Generation Safety, Solid Tumor Challenges

New strategies to overcome safety, solid tumor and other challenges associated with CAR-T therapies – and some early clinical data for patients treated with Poseida's, Celyad's and Autolus' novel products – were featured at the American Association for Cancer Research (AACR) meeting.

3d illustration of T cells or cancer cells

There are just two chimeric antigen receptor T-cell (CAR-T) therapies approved in the US, but dozens of companies already are clamoring to bring the next generation of CAR-T products to the market that address novel targets, improve toxicity and tackle the field's other big challenges.

Poseida Therapeutics Inc. and Celyad SA spoke with Scrip about their first products in the clinic and initial results in a handful of patients, but the vast majority...

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