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QUADRA Supports Broader Use For Tesaro's PARP Inhibitor Zejula

 
• By Emily Hayes

Study in late-line use of heavily pretreated ovarian cancer may bring labeling closer in line with competitors, yet with limited commercial impact, analysts say.

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Tesaro Inc.'s QUADRA study supports a supplemental NDA filing for the PARP inhibitor Zejula (niraparib) in the second half of the year for a biomarker-selected subset of heavily pretreated ovarian cancer patients, the company said in releasing top-line results of the trial April 24.

Zejula has been approved since March 2017 by the US FDA for use as a maintenance treatment in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy

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