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Alnylam Set For Transformation As Patisiran Nears Market With Data Upgrade

 
• By John Davis

Alnylam has outlined further data and analyses from the Phase III APOLLO study supporting the use of its selective interfering RNA agent, patisiran, as it nears the market for the treatment of hATTR amyloidosis.  

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Alnylam's lead product has been submitted for marketing approval • Source: Shutterstock

At the start of 2018, Alnylam Pharmaceuticals Inc. regained rights previously licensed to Sanofi on its lead product, patisiran, and the US biotech has now added to the growing excitement surrounding this new class of small interfering RNA (siRNA) agents by reporting positive all-cause hospitalization and mortality data from a post-hoc analysis of the APOLLO Phase III study.

The analysis builds on previously reported data from APOLLO that showed patisiran halted or reversed neuropathy progression in the majority of patients treated with the RNAi therapeutic for hereditary ATTR (hATTR) amyloidosis, with the strength of the therapeutic

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