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Syndax Sees Subgroup Efficacy For Entinostat Plus Keytruda In NSCLC

 
• By Joseph Haas

The company says a subgroup of lung cancer patients with high pre-treatment monocyte levels showed promising response and PFS rates in study pairing Syndax’s selective HDAC inhibitor with Merck’s Keytruda. Mature data will inform future Phase III melanoma plans.

female scientist working with microscope

Syndax Pharmaceuticals Inc. thinks it has identified a subgroup of non-small cell lung cancer (NSCLC) patients who respond well to treatment with entinostat and Merck & Co. Inc.’s Keytruda, and the company is designing a pivotal study it hopes to launch later this year in this biomarker-stratified patient subpopulation.

Syndax held an investor call May 17, following the release of abstracts for next month’s American Society of Clinical Oncology...

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