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ViiV Boosted By Early GEMINI Data, But More Details Wanted

 
• By Alexandra Shimmings

ViiV Healthcare has positive early pivotal data for its second two-drug regimen for HIV, but more reassurance is needed on the relative rates of virologic suppression in patients with low and high viral loads, as well as on the long-term risk of virologic failure. The combination should help form ViiV's defense against rival Gilead and its new triple combination Biktarvy.

French wall
Dual Therapy to Buttress ViiV's HIV Franchise

Positive top-line Phase III data for ViiV Healthcare 's second two-drug HIV product, a combination of Tivicay (dolutegravir) and the older anti-HIV drug Epivir (lamivudine), still leave experts wanting to see key details on virological failures observed in the two trials, GEMINI 1 & 2, particularly whether there is a trend for a higher rate of virologic failure in patients with high baseline viral loads (HIV RNA >100,000 copies/mL).

The studies, which compared Tivicay/Epivir to a three-drug regimen of dolutegravir and two nucleoside reverse transcriptase inhibitors, tenofovir disoproxil fumarate/emtricitabine (TDF/FTC), in a total of 1,400 treatment-naive HIV-1 infected adults...

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