ViiV Boosted By Early GEMINI Data, But More Details Wanted

ViiV Healthcare has positive early pivotal data for its second two-drug regimen for HIV, but more reassurance is needed on the relative rates of virologic suppression in patients with low and high viral loads, as well as on the long-term risk of virologic failure. The combination should help form ViiV's defense against rival Gilead and its new triple combination Biktarvy.

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Dual Therapy to Buttress ViiV's HIV Franchise

Positive top-line Phase III data for ViiV Healthcare 's second two-drug HIV product, a combination of Tivicay (dolutegravir) and the older anti-HIV drug Epivir (lamivudine), still leave experts wanting to see key details on virological failures observed in the two trials, GEMINI 1 & 2, particularly whether there is a trend for a higher rate of virologic failure in patients with high baseline viral loads (HIV RNA >100,000 copies/mL).

The studies, which compared Tivicay/Epivir to a three-drug regimen of dolutegravir and two nucleoside reverse transcriptase inhibitors, tenofovir disoproxil fumarate/emtricitabine...

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