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In DMD, Summit Falls Well Short Of Peak It Hoped For

 
• By Joseph Haas

Summit’s utrophin modulator, ezutromid, posted intriguing interim data in January, but failed to meet the primary and all secondary endpoints in a Phase II study. The UK firm discontinued development of ezutromid and will now focus on novel antibiotic candidates.

Render illustration of Clinical Trial title on medical documents

The promise of interim data reported in January didn’t hold up, as Summit Therapeutics PLC revealed June 27 that its Phase II Duchenne muscular dystrophy candidate ezutromid failed to meet the primary endpoint and all secondary endpoints in the 40-patient PhaseOut DMD study. The Oxford, UK-based firm said it has discontinued all development of the utrophin modulator and is undertaking cost-reduction measures as it switches focus to novel-mechanism antibiotic development.

Summit CEO Glyn Edwards described the study results as disappointing, but also definitive, in a same-day conference call. The company...

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