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Pfizer/Lilly's Tanezumab Reduces Osteoarthritis Pain, But Is It Safe?

 
• By Mandy Jackson

Pfizer and Lilly said tanezumab reduced pain in a Phase III osteoarthritis study, but safety is the biggest question for NGF inhibitors. Yet, while Regeneron and Teva discontinued dosing for their fasinumab at its highest dose, tanezumab was effective at both doses in its first Phase III test.

Knee joint

Pfizer Inc. and Eli Lilly & Co. said on July 18 that both doses of their nerve growth factor (NGF) inhibitor tanezumab met all three co-primary endpoints in a Phase III osteoarthritis pain study, but what remains to be seen is if the biologic is safe enough to satisfy regulators.

This drug class has a long history with clinical holds due to safety concerns, but Pfizer and Lilly reported that there were no cases of osteonecrosis and the rate of rapidly progressive osteoarthritis (RPOA) was less than 1.5% across both doses of tanezumab compared with none in the clinical trial's placebo arm

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