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Laquinimod Disappoints Again, This Time In Huntington's Disease

 
• By John Davis

Laquinimod fails to impress in a Phase II study in Huntington's disease, adding to a series of clinical trial setbacks over past years for the potential oral immunomodulator.  

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Laquinimod has not leapt over the Phase II hurdle in Huntington's disease • Source: Shutterstock

Active Biotech AB/Teva Pharmaceutical Industries Ltd.'s oral immunomodulator, laquinimod, has failed to show efficacy in another potential indication, Huntington's disease, with the mainly negative top-line results from the Phase II LEGATO-HD study adding to last year's disappointment in multiple sclerosis.

Active Biotech's share price declined by 35% in early trading on July 31, the day the Lund, Sweden-based biotech company...

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