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With Takhzyro Approval, Shire Could Reclaim HAE Prophylaxis Market From CSL Behring

 
• By Joseph Haas

Offering better efficacy than Shire’s existing HAE therapies and dosing convenience compared to CSL Behring’s prophylactic Haegarda, the specialty pharma may take back market share lost to its competitor and consolidate its leadership in the space.

Red Approved Stamp with Wooden handle Rubber Stamper Isolated on White Background.

US FDA approval for Shire PLC’s Takhzyro as a subcutaneous prophylactic for attacks of hereditary angioedema should position the company to begin winning back market share lost to CSL Behring’s prophylactic agent Haegarda. Analysts predict rapidly ramping sales for Takhzyro, reaching blockbuster totals in just a few years.

Unlike Haegarda, which inhibits HAE patients’ C1 esterase levels, Takhzyro (lanadelumab-flyo) is a kallikrein-inhibiting monoclonal antibody. It is the first antibody product approved for HAE – thought to affect roughly...

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