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BioCryst’s Oral Therapy For HAE Attacks On Track With Exploratory Phase II Success

 
• By Joseph Haas

Biocryst’s oral kallikrein inhibitor BCX7353 – already in Phase III for prophylaxis of hereditary angioedema – shows efficacy in a range of endpoints in a Phase II exploratory trial.

Medic staff at work in the laboratory. Background

Initial data showing superiority for BioCryst Pharmaceuticals Inc.’s oral kallikrein inhibitor BCX7383 over placebo on the majority of the 14 endpoints used in the ZENITH-1 study opens up the possibility that BioCryst’s candidate will become the first oral therapy for both HAE prevention and acute attacks, other than steroid therapies that have long been surpassed as standard of care.

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