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Viking’s Liver Fat Reduction Data Portend A New Competitor In NASH

 
• By Joseph Haas

In a Phase II study, Viking’s VK2809, with the same mechanism as Madrigal’s MGL-3196, shows significant liver fat reduction in NAFLD patients, along with reduction in LDL cholesterol.

Yellow road sign with a blue sky and white clouds: clinical trial

Viking Therapeutics Inc. may have a heavy hitter on its hands if results from a small Phase II study of VK2809 stand up in larger studies – the novel, liver-selective thyroid receptor beta agonist yielded a 58% reduction in liver fat from baseline over 12 weeks, according to top-line data in patients with non-alcoholic fatty liver disease (NAFLD) reported Sept. 18. NAFLD is a precursor condition to non-alcoholic steatohepatitis (NASH).

VK2809 showed a statistically significant reduction in LDL cholesterol levels in the same study, suggesting both cardiovascular and hepatic health...

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Boehringer Ingelheim Expects Two Key Approvals In Second Half Of 2025

 
• By Andrew McConaghie

The privately held German pharma firm is hoping to bring a new generation of pulmonary fibrosis and cancer drugs to market but their commercial success is not yet a certainty.

Memo Therapeutics Plans BK Virus Therapy Phase III Despite Trial Miss

 
• By Manas Mishra

Pointing to data that show a benefit in reducing viral load and the histological signs of the infection, Memo says its drug, potravitug, could become the first therapy to treat BK polyomavirus in kidney transplant recipients.

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Leo Looks To Grow In US After Hand Eczema Cream Approval

 
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More from R&D

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• By Jessica Merrill

Gefurulimab will give AstraZeneca a new option to compete against Argenx’s Vyvgart Hytrulo, which is available subcutaneously.

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Obesity Beyond GLP-1s: Amylins – The Next Frontier

 
• By Aakash Babu

In this series of articles, we look at different mechanisms of actions beyond GLP-1s that could determine the obesity drug landscape in the coming years. First on our list – amylin receptor agonists, which analysts expect to grow into a $50bn market opportunity.