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Mixed Results In AZ's DECLARE-TIMI 58 CV Trial Cloud Implications For Farxiga

 
• By Sten Stovall

While clarification on mixed DECLARE-TIMI 58 CV top-line data in diabetes patients is awaited at November's AHA meeting AstraZeneca says it is confidently pursuing independent studies of its SGLT-2 inhibitor Farxiga in heart failure and kidney disease patients.

Heart
Farxiga showed mixed results in Its Phase III DECLARE-TIMI 58 CV Trial • Source: Shutterstock

Top-line data from the Phase III DECLARE-TIMI 58 trial showed AstraZeneca PLC's diabetes therapy Farxiga (dapagliflozin) to be effective in reducing cardiovascular death and hospitalization for heart failure. However, the trial didn't meet its efficacy objective of cutting major adverse cardiovascular events in a statistically significant way, prompting some analysts to say the data would have minimal if any impact on boosting physician demand for the SGLT-2 inhibitor.

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