Can Takeda's Alunbrig Take On Roche's Alecensa In First-Line ALK-Positive Lung Cancer?

Takeda's Phase III win over Pfizer's Xalkori leaves oncologists cheering, but hankering for a head-to-head study against Alecensa, which is becoming the standard of care in the US for first-line ALK+ NSCLC.

lung illustration

Takeda Pharmaceutical Co. Ltd.'s ALK inhibitor Alunbrig is now in position to challenge next-generation anaplastic lymphoma kinase (ALK) inhibitors in mutated non-small cell lung cancer (NSCLC) after pummeling Pfizer Inc.'s first-to-market Xalkori in the Phase III ALTA-1 study.

Alunbrig (brigatinib) received accelerated US FDA approval in April 2017 for use in ALK-positive NSLC after development of tolerance to...

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