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Gilead’s FXR Agonist Posts Questionable Results In NASH, But Offers Hope In PSC

 
• By Joseph Haas

Although GS-9674’s efficacy data don’t appear as promising as that for Intercept’s competing FXR agonist OCA, Gilead seems to be building an argument that its drug has a better combination of efficacy and safety.

scientists doing lab research on digital screen

Gilead Sciences Inc. unveiled Phase II data for its farnesoid X receptor (FXR) agonist GS-9674 in non-alcoholic steatohepatitis (NASH) that raise doubts for its promise in that indication compared to other candidates from the same class, but Gilead’s drug fared better in a primary sclerosing cholangitis (PSC) trial, showing improvements in liver biochemistry and markers of cholestasis.

A competing NASH candidate, Intercept Pharmaceuticals Inc.'s obeticholic acid (OCA), showed the ability to reduce both fibrosis and steatosis...

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• By Aakash Babu

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