Ovarian Cancer Pipeline Review: Sponsors Plan Frontline Punch, Smart Combinations

Combination studies of drugs for ovarian cancer have heavy focus on PARP, PD-1/L1 and VEGF mechanisms.

Ovarian cancer

Ovarian cancer treatment has been rejuvenated in recent years by the introduction of the PARP inhibitors, starting in relapsed disease for patients with BRCA mutations. Now, sponsors are tackling ovarian cancer in earlier stages with the goal of boosting initial remissions.

The pace of research in ovarian cancer has accelerated in the past few years – moving beyond BRCA and beyond monotherapy toward earlier lines of disease and "smart combinations," in...

Current Treatment Options

In addition to mainstay treatment with platinum-based chemotherapy, three PARP inhibitors are approved as monotherapy second-line maintenance treatments for recurrent ovarian cancer that is still responsive to platinum-based...

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